Dr. Murray Brilliant, a researcher at Marshfield Clinic, explains that pharmacogenomics is simply the idea that an individual's genetic variants can help determine how they may react to a particular drug.
Dr. Dan Roden, a researcher at Vanderbilt University, explains that if you give the same dose of a drug to a large number of people, responses will vary. Some people will have a great response, some will have no response, while others will experience adverse side effects. Some of this variability resides in our genes. The science of pharmacogenetics is the science of trying to understand the genes that contribute to the variability of drug action.
Dr. Iftikhar Kullo, a researcher at Mayo Clinic, explains that pharmacogenomics is the science of using genetic information to determine medications an individual should receive. It can help tailor the right drug or the right dose an individual should receive. It can also help prevent adverse side effects an individual may experience as a consequence of taking a drug. It is a step towards individualized medicine.
Dr. Ingrid Holm, a researcher at Boston Children's Hospital, explains that pharmacogenomics uses information about genetics to tailor drugs to different individuals. Some people may metabolize certain drugs particularly quickly, while others may be slow metabolizers. Genetic testing may help us predict drug response and therefore improve treatment.