Children's Hospital of Philadelphia
Dr. Hakon Hakonarson explains that the eMERGE consortium is a collaborative network of 10 medical centers, working to use genomic information to improve healthcare. Dr. Hakonarson directs CHOPs involvement in the program, and aims to use genetic information from 60,000 children to help identify the best treatments for patients at CHOP.
Dr. Hakon Hakonarson explains that genetic testing can now be used to predict responses to certain medications. This will help to prevent negative reactions and improve healthcare.
Dr. Hakon Hakonarson explains that extremely stringent measures are taken to protect patient privacy in genetic research studies at CHOP and elsewhere. It is critically important to ensure the risk to patients is minimal.
Dr. Hakon Hakonarson explains that genetic testing can now be used to predict responses to asthma medications - helping to decide what medication will help a patient the most, what dose should work best, and what medications to avoid.
Dr. Hakon Hakonarson explains that genetic testing can now be used to predict responses to cancer medications - including those used to treat leukemia, lymphoma, and others. These cancers are often treated with thiopruines. However, certain individuals have a genetic difference in a gene called TPMT, which means their body has problems processing the drug. For these people, the drug can accumulate in the body, and become toxic. Genetic testing allows us to identify these people prior to treatment, and therefore avoid this potentially negative reaction.
Dr. Hakon Hakonarson explains that people can response very differently to pain medications. For morphine and other analgesics, some individuals may require a 10-fold increase in dosage. Genetic testing can help determine the dosage of morphine a person should receive. In turn, this will result in improved healthcare.
Dr. Hakon Hakonarson explains that genetic testing can now be used to predict responses to certain medications - including Prilosec/omeprazole. Omeprazole (also known as Prilosec) is used to treat gastroesophageal reflux disease (GERD). We can now test for genetic variations in two genes - called CYP2D6 and CYP2C19. Test results can help decide the appropriate medication/dosage.